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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Bulk transcriptomic profiles of mouse testes in response to male environmental exposures in the young FVB background

ABSTRACT: This study includes raw data of testis RNA-seq profiles from treated (nABX & LPHS, with nABX: non-absorbable antibiotics LPHS: low-protein, high sugar diet) and control (CON) males of young (10-11 weeks) FVB background. Sequencing was done using 40bp paired-end reads on a NextSeq500 sequencer, obtaining an average of 25 million reads per sample.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Mus musculus

SUBMITTER: Charles Girardot

PROVIDER: E-MTAB-14637 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Bulk transcriptomic profiles of mouse testes in response to male environmental exposures across age and genetic background

Project description:This study includes raw data of testis RNA-seq profiles from treated (nABX & LPHS, with nABX: non-absorbable antibiotics and LPHS: low-protein, high sugar diet) and control (CON) males of mature (57-62 weeks) and young (9-11 weeks) FVB & C57BL/6J backgrounds. Sequencing was done using 40bp paired-end reads on a NextSeq500 sequencer, obtaining an average of 25 million reads per sample.

2024-11-22 | E-MTAB-14638 | biostudies-arrayexpress

Small RNA profiles of mouse sperm in response to male environmental exposures across age and genetic background

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Single-embryo transcriptomic profiles of mouse blastocysts in response to paternal environmental exposures in young FVB background

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In-depth proteomic analysis of nasal fluids from patients with chronic rhinosinusitis and nasal polyps by data-independent acqusition

Project description:Antibiotics are commonly prescribed to treat chronic rhinosinusitis (CRS). However, the effects of antibiotics on the microbiome and secreted proteome remain unknown in regard to CRS.We analyzed the effects of antibiotics on the nasal secreted proteome inthe context of CRS using data-independent acqusition proteomics approach.

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Persistent chromatin modifications induced by high fat diet

Project description:Obesity is a highly heritable complex disease that results from the interaction of multiple genetic and environmental factors. Formerly obese individuals are susceptible to metabolic disorders later in life, even after lifestyle changes are made to mitigate the obese state. This is reminiscent of the metabolic memory phenomenon originally observed for persistent complications in diabetic patients, despite subsequent glycemic control. Epigenetic modifications represent a potential mediator of this observed memory. We previously demonstrated that a high fat (HF) diet leads to changes in chromatin accessibility in the mouse liver. The regions of greatest chromatin changes in accessibility are largely strain dependent, indicating a genetic component in diet-induced chromatin alterations. We have now examined the persistence of diet-induced chromatin accessibility changes upon diet reversal in two strains of mice. We find that a substantial fraction of loci that undergo chromatin accessibility changes with HF diet remain in the remodeled state after diet reversal in C57BL/6J mice. In contrast, the vast majority of diet-induced chromatin accessibility changes in A/J mice are transient. Our data also indicate that the persistent chromatin accessibility changes observed in C57BL/6J are associated with specific transcription factors and histone posttranslational modifications. The persistent loci identified here are likely to be contributing to the overall phenotype and are attractive targets for therapeutic intervention. Examination of chromatin remodeling with FAIRE-seq in livers of C57BL/6J and A/J mice on three diet regimen: 1) control diet for 16 weeks, 2) high fat diet for 16 weeks, or 3) high fat diet for 8 weeks with control diet for 8 weeks. These chromatin profiles were complemented with gene expression data (RNA-seq)

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A preclinical mouse model of nonalcoholic steatohepatitis and hepatocellular cancer that mimics human disease

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Effects of Iron Deficiency and Risperidone treatment on the rat frontal cortex

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Proteomic detection of mouse liver

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