Ontology highlight
ABSTRACT:
INSTRUMENT(S): AB SOLiD 5500
ORGANISM(S): Mus musculus
SUBMITTER: Roberto Papait
PROVIDER: E-MTAB-1506 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Papait Roberto R Cattaneo Paola P Kunderfranco Paolo P Greco Carolina C Carullo Pierluigi P Guffanti Alessandro A Viganò Valentina V Stirparo Giuliano Giuseppe GG Latronico Michael V G MV Hasenfuss Gerd G Chen Ju J Condorelli Gianluigi G
Proceedings of the National Academy of Sciences of the United States of America 20131127 50
Cardiac hypertrophy, initially an adaptive response of the myocardium to stress, can progress to heart failure. The epigenetic signature underlying this phenomenon is poorly understood. Here, we report on the genome-wide distribution of seven histone modifications in adult mouse cardiomyocytes subjected to a prohypertrophy stimulus in vivo. We found a set of promoters with an epigenetic pattern that distinguishes specific functional classes of genes regulated in hypertrophy and identified 9,207 ...[more]