Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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IGR_MYOGENIC_STUDY_PD


ABSTRACT: Transcriptome profiling of in vitro grown primary myoblasts isolated from biopsies originating from six healthy individuals and matching myotubes grown in myogenic differentiation medium. Two color experiment: RNA extracted from individual myoblast and myotube lines was Cy5-labeled, mixed with with a pool of RNA samples labeled with Cy3 and hybridized to Gene Expression microarrays (Agilent).

ORGANISM(S): Homo sapiens

SUBMITTER: Philippe DESSEN 

PROVIDER: E-MTAB-1577 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant hereditary neuromuscular disorder linked to the deletion of an integral number of 3.3-kb-long macrosatellite repeats (D4Z4) within the subtelomeric region of chromosome 4q. Most genes identified in this region are overexpressed in FSHD myoblasts, including the double homeobox genes DUX4 and DUX4c. We have carried out a simultaneous miRNome/transcriptome analysis of FSHD and control primary myoblasts. Of 365 microRNAs (miRNAs)  ...[more]

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