Dataset Information
Transcription profiling by array of insecticide resistance in field populations of Anopheles funestus in Benin
Ontology highlight
ABSTRACT:
ORGANISM(S): Anopheles funestus
SUBMITTER: Charles Wondji
PROVIDER: E-MTAB-1578 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in a major malaria vector.
Genome biology 20140225 2
<h4>Background</h4>Metabolic resistance to insecticides is the biggest threat to the continued effectiveness of malaria vector control. However, its underlying molecular basis, crucial for successful resistance management, remains poorly characterized.<h4>Results</h4>Here, we demonstrate that the single amino acid change L119F in an upregulated glutathione S-transferase gene, GSTe2, confers high levels of metabolic resistance to DDT in the malaria vector Anopheles funestus. Genome-wide transcrip ...[more]
