Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

BIN-67 small cell ovarian carcinoma SNP array

ABSTRACT: The biology of small cell ovarian carcinoma of the hypercalcemic type (SCCOHT), which is a rare and aggressive form of ovarian cancer, is poorly understood. Tumourigenicity, in vitro growth characteristics, genetic and genomic anomalies, and sensitivity to standard and novel chemotherapeutic treatments were investigated in the unique SCCOHT cell line, BIN-67, to provide further insight in the biology of this rare type of ovarian cancer. Chromosomal anomalies in BIN-67 cells were inferred using the Infinium? genotyping technology with the HumanHap300-Duo Genotyping BeadChip (Illumina, San Diego, CA, USA). This BeadChip contains about 318,000 genetic markers within approximately a 5 kb median SNP spacing. Genotyping and imaging using BeadStudio Data Analysis software (Illumina, San Diego, CA, USA) were performed at the McGill University and Genome Quebec Innovation Centre (Montreal, QC).

ORGANISM(S): Homo sapiens

SUBMITTER: Suzanna Arcand

PROVIDER: E-MTAB-1584 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics.

Gamwell Lisa F LF Gambaro Karen K Merziotis Maria M Crane Colleen C Arcand Suzanna L SL Bourada Valerie V Davis Christopher C Squire Jeremy A JA Huntsman David G DG Tonin Patricia N PN Vanderhyden Barbara C BC

Orphanet journal of rare diseases 20130221

<h4>Background</h4>The biology of small cell ovarian carcinoma of the hypercalcemic type (SCCOHT), which is a rare and aggressive form of ovarian cancer, is poorly understood. Tumourigenicity, in vitro growth characteristics, genetic and genomic anomalies, and sensitivity to standard and novel chemotherapeutic treatments were investigated in the unique SCCOHT cell line, BIN-67, to provide further insight in the biology of this rare type of ovarian cancer.<h4>Method</h4>The tumourigenic potential ...[more]

PMID: 23433318

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Dataset Information

BIN-67 small cell ovarian carcinoma SNP array

Publications

Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics.

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