Unknown,Transcriptomics,Genomics,Proteomics

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MLE ChIP-seq

ABSTRACT: Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) was carried out on wild-type Schneider (S2) cells using specific MLE antibodies to identify binding sites for MLE in the Drosophila genome

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Filipe Tavares-Cadete 

PROVIDER: E-MTAB-1705 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dosage compensation in Drosophila is an epigenetic phenomenon utilizing proteins and long noncoding RNAs (lncRNAs) for transcriptional upregulation of the male X chromosome. Here, by using UV crosslinking followed by deep sequencing, we show that two enzymes in the Male-Specific Lethal complex, MLE RNA helicase and MSL2 ubiquitin ligase, bind evolutionarily conserved domains containing tandem stem-loops in roX1 and roX2 RNAs in vivo. These domains constitute the minimal RNA unit present in multi  ...[more]

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