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Transcription profiling of muscle and liver tissue in collagen-induced arthritis (CIA) and control mice treated with increasing doses of prednisolone

ABSTRACT: Prednisolone is a potent anti-inflammatory glucocorticoid (GC) but chronic use is hampered by metabolic side effects. Although GCs are predominantly prescribed for treatment of inflammatory conditions, little is known about their long-term effects on gene-expression in-vivo during inflammation. Here, we aimed to identify genes underlying prednisolone-induced metabolic side effects in a complex in-vivo inflammatory setting after long-term treatment. We performed whole-genome expression profiling in liver and muscle from arthritic and non-arthritic mice treated with several doses of prednisolone for three weeks.

ORGANISM(S): Mus musculus

SUBMITTER: Sandrine Ellero-Simatos

PROVIDER: E-MTAB-1765 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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