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Inflammatory Bowel Disease StOlav

ABSTRACT: Expression profiling of human colon mucosa samples aquired from inflammatory bowel disease patients and healthy controls. Expression profiling was done using Illumina Human HT-12 arrays, and data analysis was performed using tools from the Bioconductor package

ORGANISM(S): Homo Sapiens

DISEASE(S): unaffected

SUBMITTER: Atle Granlund

PROVIDER: E-MTAB-184 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation.

van Beelen Granlund Atle A Østvik Ann Elisabet AE Brenna Øystein Ø Torp Sverre H SH Gustafsson Bjørn I BI Sandvik Arne Kristian AK

Cell and tissue research 20130322 3

The regenerating islet-derived (REG) gene family encodes a group of proteins highly expressed in several human pathologies, many of which are associated with epithelial inflammation. All human family members, namely REG1A, REG1B, REG3A and REG4, are closely related in genomic sequence and all are part of the c-type lectin superfamily. REGs are highly expressed during inflammatory bowel disease (IBD)-related colonic inflammation and the in vivo expression pattern of REG1A and REG4 has been locali ...[more]

PMID: 23519454

Publication: 1/2

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