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Transcription profiling of different human melanoma cells in response to 5-aza-deoxycytidine

ABSTRACT: (subset of yale_halaban_skinspore_1) expression analysis in response to 5-aza-deoxycytidine and normal melanocytes versus melanoma.

ORGANISM(S): Homo sapiens

SUBMITTER: Ruth Halaban

PROVIDER: E-MTAB-185 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications.

Halaban Ruth R Krauthammer Michael M Pelizzola Mattia M Cheng Elaine E Kovacs Daniela D Sznol Mario M Ariyan Stephan S Narayan Deepak D Bacchiocchi Antonella A Molinaro Annette A Kluger Yuval Y Deng Min M Tran Nam N Zhang Wengeng W Picardo Mauro M Enghild Jan J JJ

PloS one 20090223 2

Decitabine, an epigenetic modifier that reactivates genes otherwise suppressed by DNA promoter methylation, is effective for some, but not all cancer patients, especially those with solid tumors. It is commonly recognized that to overcome resistance and improve outcome, treatment should be guided by tumor biology, which includes genotype, epigenotype, and gene expression profile. We therefore took an integrative approach to better understand melanoma cell response to clinically relevant dose of ...[more]

PMID: 19234609

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Expression in Aneuploid Drosophila S2 Cells

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