Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000
ORGANISM(S): Mus musculus
SUBMITTER: Alejandro Reyes
PROVIDER: E-MTAB-1963 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Klimmeck Daniel D Cabezas-Wallscheid Nina N Reyes Alejandro A von Paleske Lisa L Renders Simon S Hansson Jenny J Krijgsveld Jeroen J Huber Wolfgang W Trumpp Andreas A
Stem cell reports 20140925 5
Hematopoietic stem cells possess lifelong self-renewal activity and generate multipotent progenitors that differentiate into lineage-committed and subsequently mature cells. We present a comparative transcriptome analysis of ex vivo isolated mouse multipotent hematopoietic stem/progenitor cells (Lin(neg)SCA-1(+)c-KIT(+)) and myeloid committed precursors (Lin(neg)SCA-1(neg)c-KIT(+)). Our data display dynamic transcriptional networks and identify a stem/progenitor gene expression pattern that is c ...[more]