Tri-KIX +/- c-Myb MEFs
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Lawryn Kasper
PROVIDER: E-MTAB-1973 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression.
Kasper Lawryn H LH Fukuyama Tomofusa T Lerach Stephanie S Chang Yunchao Y Xu Wu W Wu Song S Boyd Kelli L KL Brindle Paul K PK
PloS one 20131210 12
Adult blood cell production or definitive hematopoiesis requires the transcription factor c-Myb. The closely related KAT3 histone acetyltransferases CBP (CREBBP) and p300 (EP300) bind c-Myb through their KIX domains and mice homozygous for a p300 KIX domain mutation exhibit multiple blood defects. Perplexingly, mice homozygous for the same KIX domain mutation in CBP have normal blood. Here we test the hypothesis that the CBP KIX domain contributes subordinately to hematopoiesis via a genetic int ...[more]
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