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Ontogeny of Innate Immunity in Oral Mucosa - Cross Sectional

ABSTRACT: mRNA microarray profiling was performed on healthy gingival biopsies from nonhuman primates (NHPs) (between 3 and 23 years old, and periodontitis gingival biopsies from NHPs (12-22 years old)

ORGANISM(S): Macaca mulatta

SUBMITTER: Octavio Gonzalez

PROVIDER: E-MTAB-1977 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Effects of aging on apoptosis gene expression in oral mucosal tissues.

Gonzalez Octavio A OA Novak M John MJ Kirakodu Sreenatha S Stromberg Arnold J AJ Shen Shu S Orraca Luis L Gonzalez-Martinez Janis J Ebersole Jeffrey L JL

Apoptosis : an international journal on programmed cell death 20130301 3

Apoptotic processes are important for physiologic renewal of an intact epithelial barrier and contribute some antimicrobial resistance for bacteria and viruses, as well as anti-inflammatory effects that benefits the mucosa. The oral cavity presents a model of host-bacterial interactions at mucosal surfaces, in which a panoply of microorganisms colonizes various niches in the oral cavity and creates complex multispecies biofilms that challenge the gingival tissues. This report details gene expres ...[more]

PMID: 23334583

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