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CcRCC_SNParray

ABSTRACT: Copy number analysis of Affymetrix 250K SNP arrays was performed for 240 clear cell RCC samples. There are also 234 samples from adjacent normal kidney or peripheral blood, which were used as references for copy number inference.

ORGANISM(S): Homo sapiens

SUBMITTER: Yusuke Sato

PROVIDER: E-MTAB-2015 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrated molecular analysis of clear-cell renal cell carcinoma.

Sato Yusuke Y Yoshizato Tetsuichi T Shiraishi Yuichi Y Maekawa Shigekatsu S Okuno Yusuke Y Kamura Takumi T Shimamura Teppei T Sato-Otsubo Aiko A Nagae Genta G Suzuki Hiromichi H Nagata Yasunobu Y Yoshida Kenichi K Kon Ayana A Suzuki Yutaka Y Chiba Kenichi K Tanaka Hiroko H Niida Atsushi A Fujimoto Akihiro A Tsunoda Tatsuhiko T Morikawa Teppei T Maeda Daichi D Kume Haruki H Sugano Sumio S Fukayama Masashi M Aburatani Hiroyuki H Sanada Masashi M Miyano Satoru S Homma Yukio Y Ogawa Seishi S

Nature genetics 20130624 8

Clear-cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer and its molecular pathogenesis is incompletely understood. Here we report an integrated molecular study of ccRCC in which ≥100 ccRCC cases were fully analyzed by whole-genome and/or whole-exome and RNA sequencing as well as by array-based gene expression, copy number and/or methylation analyses. We identified a full spectrum of genetic lesions and analyzed gene expression and DNA methylation signatures and determined the ...[more]

PMID: 23797736

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