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K450 arrays leukocyte subsets

ABSTRACT: DNA methylation profiles of primary human leukocyte subsets. Complementary MeDIP-seq data for the same samples have been deposited in ArrayExpress under accession number E-ERAD-179 (https://www.ebi.ac.uk/arrayexpress/experiments/E-ERAD-179/) .

ORGANISM(S): Homo sapiens

SUBMITTER: Matthias Zilbauer

PROVIDER: E-MTAB-2145 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions.

Zilbauer Matthias M Rayner Tim F TF Clark Christine C Coffey Alison J AJ Joyce Chris J CJ Palta Priit P Palotie Aarno A Lyons Paul A PA Smith Kenneth G C KG

Blood 20131024 25

DNA methylation is an important mechanism by which gene transcription and hence cellular function are regulated. Here, we provide detailed functional genome-wide methylome maps of 5 primary peripheral blood leukocyte subsets including T cells, B cells, monocytes/macrophages, and neutrophils obtained from healthy individuals. A comparison of these methylomes revealed highly specific cell-lineage and cell-subset methylation profiles. DNA hypomethylation is known to be permissive for gene expressio ...[more]

PMID: 24159175

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