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Urothelial in vitro differentiation series

ABSTRACT: Aim: to study gene expression changes induced when in vitro cultures of normal human urothelial cells are induced to differentiate using two previously published methods: Varley et al (2004) and Cross et al (2005)

ORGANISM(S): Homo sapiens

SUBMITTER: Jennifer Southgate

PROVIDER: E-MTAB-2188 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of ELF3 as an early transcriptional regulator of human urothelium.

Böck Matthias M Hinley Jennifer J Schmitt Constanze C Wahlicht Tom T Kramer Stefan S Southgate Jennifer J

Developmental biology 20131225 2

Despite major advances in high-throughput and computational modelling techniques, understanding of the mechanisms regulating tissue specification and differentiation in higher eukaryotes, particularly man, remains limited. Microarray technology has been explored exhaustively in recent years and several standard approaches have been established to analyse the resultant datasets on a genome-wide scale. Gene expression time series offer a valuable opportunity to define temporal hierarchies and gain ...[more]

PMID: 24374157

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