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RNAseq of S. stercoralis PV001 strain L3i activation

ABSTRACT: RNAseq study to examine regulation of S. stercoralis transcripts during L3i activation

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Strongyloides_stercoralis

SUBMITTER: Stoltzfus Jonathan

PROVIDER: E-MTAB-2192 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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cGMP and NHR signaling co-regulate expression of insulin-like peptides and developmental activation of infective larvae in Strongyloides stercoralis.

Stoltzfus Jonathan D JD Bart Stephen M SM Lok James B JB

PLoS pathogens 20140710 7

The infectious form of the parasitic nematode Strongyloides stercoralis is a developmentally arrested third-stage larva (L3i), which is morphologically similar to the developmentally arrested dauer larva in the free-living nematode Caenorhabditis elegans. We hypothesize that the molecular pathways regulating C. elegans dauer development also control L3i arrest and activation in S. stercoralis. This study aimed to determine the factors that regulate L3i activation, with a focus on G protein-coupl ...[more]

PMID: 25010340

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