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Unknown,Transcriptomics,Genomics,Proteomics

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Heatshock-Coldshock

ABSTRACT: Heatshock (30 to 37 deg C) and Coldshock (37 to 30 deg C) experiment looking at 5, 15, 30, 45 and 60 mins after the temp change in each condition.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Philip Lijnzaad

PROVIDER: E-MTAB-2219 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cell cycle population effects in perturbation studies.

O'Duibhir Eoghan E Lijnzaad Philip P Benschop Joris J JJ Lenstra Tineke L TL van Leenen Dik D Groot Koerkamp Marian J A MJ Margaritis Thanasis T Brok Mariel O MO Kemmeren Patrick P Holstege Frank C P FC

Molecular systems biology 20140621

Growth condition perturbation or gene function disruption are commonly used strategies to study cellular systems. Although it is widely appreciated that such experiments may involve indirect effects, these frequently remain uncharacterized. Here, analysis of functionally unrelated Saccharyomyces cerevisiae deletion strains reveals a common gene expression signature. One property shared by these strains is slower growth, with increased presence of the signature in more slowly growing strains. The ...[more]

PMID: 24952590

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