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Unknown,Transcriptomics,Genomics,Proteomics

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Bone signaling in rat middle ear and cochlea by transcription profiling

ABSTRACT: * Bone signaling in middle ear development *
Common middle ear diseases, such as chronic suppurative otitis media and cholesteatoma, may affect bone behavior in the middle ear air cell system.
This study analyzed gene expression of bone-related signaling factors and gene sets from lining tissues in the developing middle ear of the rat. Candidate gene products were compared with previously published data on middle ear bone metabolism.
Microarray technology was used to identify bone-related genes and gene sets, which were differentially expressed between the adult (quiescent) bulla and young (resorbing/forming) bulla.

* Gene expression of the otic capsule *
The behavior of bone cells within the otic capsule is unique. After occification localized bone remodeling is virtually absent. Human otosclerosis is a localized disease within the otic capsule where the bone starts to remodel pathologically. Disease etiology is unknown and the pathogenesis is only partially elucidated.

The objective of this study is to measure bone-related gene expression of the otic capsule in order to reveal additionally signaling factors responsible for the absent bone remodeling within the otic capsule.

Microarray technology was used to determine genes involved in the bone metabolism, which were differentially expressed between lining tissues from the otic capsule and lining tissues from the middle ear of the rat.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Tomas Martin-Bertelsen

PROVIDER: E-MTAB-2336 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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