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BP001-002-pub:The genomic landscape of compensatory evolution

ABSTRACT: This hybset contains the expression profiles of several yeast deletion mutants, grown after normal and evolution conditions

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Marian Groot Koerkamp

PROVIDER: E-MTAB-2352 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The genomic landscape of compensatory evolution.

Szamecz Béla B Boross Gábor G Kalapis Dorottya D Kovács Károly K Fekete Gergely G Farkas Zoltán Z Lázár Viktória V Hrtyan Mónika M Kemmeren Patrick P Groot Koerkamp Marian J A MJ Rutkai Edit E Holstege Frank C P FC Papp Balázs B Pál Csaba C

PLoS biology 20140826 8

Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects through compensatory genetic changes. This process can potentially influence directions of adaptive evolution by enabling evolutionary routes that are otherwise inaccessible. Therefore, the extent to which compensatory mutations shape genomic evolut ...[more]

PMID: 25157590

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BP001-002: The genomic landscape of compensatory evolution

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