Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina Genome Analyzer IIx
ORGANISM(S): Homo sapiens
SUBMITTER: Anne Seifert
PROVIDER: E-MTAB-2368 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Seifert Anne A Schofield Pietà P Barton Geoffrey J GJ Hay Ronald T RT
Science signaling 20150707 384
The small ubiquitin-like modifier 2 (SUMO-2) is required for survival when cells are exposed to treatments that induce proteotoxic stress by causing the accumulation of misfolded proteins. Exposure of cells to heat shock or other forms of proteotoxic stress induces the conjugation of SUMO-2 to proteins in the nucleus. We investigated the chromatin landscape of SUMO-2 modifications in response to heat stress. Through chromatin immunoprecipitation assays coupled to high-throughput DNA sequencing a ...[more]