Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ian Donaldson
PROVIDER: E-MTAB-830 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Odrowaz Zaneta Z Sharrocks Andrew D AD
PLoS genetics 20120510 5
Eukaryotic transcription factors are grouped into families and, due to their similar DNA binding domains, often have the potential to bind to the same genomic regions. This can lead to redundancy at the level of DNA binding, and mechanisms are required to generate specific functional outcomes that enable distinct gene expression programmes to be controlled by a particular transcription factor. Here we used ChIP-seq to uncover two distinct binding modes for the ETS transcription factor ELK1. In o ...[more]