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Transcriptional profiling of cerebrospinal fluid cells of multiple sclerosis patients

ABSTRACT: RNA was isolated from fresh cerebrospinal fluid samples of multiple sclerosis and control patients and analyzed by hybridization of HG U133 plus 2.0 arrays in order to investigate disease mechanisms of multiple sclerosis and to identify transcriptional biomarker

ORGANISM(S): Homo sapiens

SUBMITTER: Andre Mueller

PROVIDER: E-MTAB-2374 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cerebrospinal hepatocyte growth factor levels correlate negatively with disease activity in multiple sclerosis.

Müller Andre Michael AM Jun Esther E Conlon Hana H Sadiq Saud Ahmed SA

Journal of neuroimmunology 20120706 1-2

The hepatocyte growth factor (HGF) is a pleiotropic cytokine with neuroprotective and anti-inflammatory properties. Additionally, it enhances axonal outgrowth and oligodendroglial maturation. We studied the expression of HGF by cells derived from cerebrospinal fluid (CSF), quantified HGF in CSF samples and investigated the glial expression of HGF in vitro. We found decreased expression of HGF in CSF cells as well as reduced CSF but not plasma HGF protein levels in MS. MS patients with active dis ...[more]

PMID: 22771249

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2012-05-08 | E-GEOD-37664 | biostudies-arrayexpress

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