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Transcription profiling by array of human HL-60 cells treated with anacardic acid

ABSTRACT: The aim of the experiment was to identify the genes up or downregulated by hyposumoylation induced by anacardic acid, an inhibitor of SUMO activating enzyme, in Acute Myeloid Leukemia cell line HL-60

ORGANISM(S): Homo sapiens

SUBMITTER: TONY KAOMA

PROVIDER: E-MTAB-2382 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The ROS/SUMO axis contributes to the response of acute myeloid leukemia cells to chemotherapeutic drugs.

Bossis Guillaume G Sarry Jean-Emmanuel JE Kifagi Chamseddine C Ristic Marko M Saland Estelle E Vergez François F Salem Tamara T Boutzen Héléna H Baik Hayeon H Brockly Frédérique F Pelegrin Mireia M Kaoma Tony T Vallar Laurent L Récher Christian C Manenti Stéphane S Piechaczyk Marc M

Cell reports 20140605 6

Chemotherapeutic drugs used in the treatment of acute myeloid leukemias (AMLs) are thought to induce cancer cell death through the generation of DNA double-strand breaks. Here, we report that one of their early effects is the loss of conjugation of the ubiquitin-like protein SUMO from its targets via reactive oxygen species (ROS)-dependent inhibition of the SUMO-conjugating enzymes. Desumoylation regulates the expression of specific genes, such as the proapoptotic gene DDIT3, and helps induce ap ...[more]

PMID: 24910433

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