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Biomarkers of hippocampal gene expression in a mouse restraint chronic stress model

ABSTRACT: Acute stress provides many beneficial effects whereas chronic stress contributes to a variety of human health problems. The objective of this study was to use a rodent model to uncover hippocampal gene signatures associated with prolonged chronic stress which could potentially serve as biomarkers and therapeutic targets for early diagnosis and pharmacological intervention for stress induced disease. Mice were subjected to restraint stress over 7 consecutive days and gene expression changes in the hippocampus were analyzed at 3, 12 and 24 hours following the final restraint treatment. Data indicated that mice exposed to chronic restraint stress exhibit a differential gene expression profile compared to non-stressed controls. The greatest differences were observed 12 and 24 hrs following the final stress test.

ORGANISM(S): Mus musculus

SUBMITTER: Gary Hardiman

PROVIDER: E-MTAB-2402 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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