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AngioEvasion_001

ABSTRACT: We aim to identify the molecular mechanisms underlying LLC tumor evasion from endogenous angiogenesis inhibitor Endostatin in-vivo. Tumor cells were inoculated in C57/BL6 mice. Mice were treated with muFc-endostatin (20ﾵg/day) until the tumors evade therapy. Tumors were re-implanted in a new batch of mice for 4 consecutive in-vivo passages. Passage four (P4) endostatin-treated and control tumors were profiled. Significantly upregulated genes attributed to endostatin resistance were identified. Their gene expression levels were assessed by real-time PCR (Taqmanﾮ probe). Candidate genes were further functionally evaluated in-vivo using inhibitors.

ORGANISM(S): Mus musculus

SUBMITTER: Amir Abdollahi

PROVIDER: E-MTAB-2529 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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