ChIP-Seq for RIP140, using the human breast cancer cell line MCF-7 in the absence of hormone or after treatment with Estradiol
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina Genome Analyzer II
ORGANISM(S): Homo sapiens
SUBMITTER: Gordon Brown
PROVIDER: E-MTAB-2576 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Complex formation and function of estrogen receptor α in transcription requires RIP140.
Rosell Meritxell M Nevedomskaya Ekaterina E Stelloo Suzan S Nautiyal Jaya J Poliandri Ariel A Steel Jennifer H JH Wessels Lodewyk F A LF Carroll Jason S JS Parker Malcolm G MG Zwart Wilbert W
Cancer research 20140821 19
RIP140 is a transcriptional coregulator involved in energy homeostasis, ovulation, and mammary gland development. Although conclusive evidence is lacking, reports have implicated a role for RIP140 in breast cancer. Here, we explored the mechanistic role of RIP140 in breast cancer and its involvement in estrogen receptor α (ERα) transcriptional regulation of gene expression. Using ChIP-seq analysis, we demonstrate that RIP140 shares more than 80% of its binding sites with ERα, colocalizing with i ...[more]
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