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Gene-expression in peripheral blood mononuclear cells from untreated MS patients

ABSTRACT: The aim of this study was to identify differentially expressed genes in peripheral blood mononuclear cells from MS patients that were responders or non-responders to the neuroantigen myelin basic protein. Using microarray we measured mRNA-expression levels in freshly isolated peripheral blood mononuclear cells from 17 untreated patients with multiple sclerosis. Based on studies, measuring the responses of blood derived T-cells to myelin basic protein ex vivo, these 17 untreated MS-patients can be divided into two groups: 4 of the untreated multiple sclerosis patients had T-cells that responded to myelin basic protein ex vivo whereas 13 untreated MS patients had T-cells that did not respond to myelin basic protein ex vivo.

ORGANISM(S): Homo sapiens

SUBMITTER: Lars Boernsen

PROVIDER: E-MTAB-2707 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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