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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of intestinal tissue from Drosophila w1118 and p38c null mutation flies

ABSTRACT: We investigated changes in transcriptome of Drosophila female guts in wild-type (w1118) flies and p38c mutant flies (p38c7B1) aged 3-5 days.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Sveta Chakrabarti

PROVIDER: E-MTAB-2740 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine.

Chakrabarti Sveta S Poidevin Mickaël M Lemaitre Bruno B

PLoS genetics 20140925 9

The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and biological stresses p38 kinases phosphorylate various substrates, transcription factors of the ATF family and other protein kinases, regulating cellular adaptation to stress. The Drosophila genome encodes three p38 kinases named p38a, p38b and p38c. In this study, we have analyzed the role of p38c i ...[more]

PMID: 25254641

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