Evaluation of gene expression profiling and biochemical response of lung and heart of mice exposed to season fine particulate matter PM2.5

ABSTRACT: Pathways leading to cardiovascular effects of particulate matter exposure have been linked to oxidative stress, pulmonary and systemic inflammation, endothelial cell dysfunction, atherosclerosis and altered cardiac autonomic function. PM2.5 levels in Milano are greater than those observed in urban sites in Europe, while its chemical composition is similar to those of other European cities. Winter fine particles (PM2.5win) are characterized by the presence of nitrate, organic carbon fraction (with a quite high polycyclic aromatic hydrocarbons content) and elements (Pb, Al, Zn, V, Fe, Cr and others), with a negligible endotoxin content. To elucidate the changes at molecular level, we examined the toxic effects elicited after repeated Milano PM2.5win exposure in BALB/c mice, focusing both on

ORGANISM(S): Mus musculus

SUBMITTER: Cristina Battaglia 

PROVIDER: E-MTAB-2751 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress