Proteomics

Dataset Information

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Effects of retene, pyrene and phenanthrene on the cardiac proteome of the rainbow trout larva


ABSTRACT: The mechanisms of cardiotoxicity of the three widespread model polycyclic aromatic hydrocarbons (PAHs) retene, pyrene and phenanthrene were explored in rainbow trout (Oncorhyncus mykiss) early life stages. Newly hatched larvae were exposed to sublethal doses of each individual PAH causing no detectable morphometric alterations. Changes in the cardiac proteome were assessed after 7 or 14 days of exposure to each PAH.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Oncorhynchus Mykiss (rainbow Trout) (salmo Gairdneri)

TISSUE(S): Heart

SUBMITTER: Cyril Rigaud  

LAB HEAD: Eeva-Riikka Vehniäinen

PROVIDER: PXD017294 | Pride | 2020-08-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
170829_ERV49.raw Raw
170829_ERV50.raw Raw
170829_ERV51.raw Raw
170829_ERV52.raw Raw
170829_ERV53.raw Raw
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Publications

Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, part 2 - Proteomics and metabolomics.

Rigaud Cyril C   Eriksson Andreas A   Rokka Anne A   Skaugen Morten M   Lihavainen Jenna J   Keinänen Markku M   Lehtivuori Heli H   Vehniäinen Eeva-Riikka ER  

The Science of the total environment 20200725


Polycyclic aromatic hydrocarbons (PAHs) are global contaminants of concern. Despite several decades of research, their mechanisms of toxicity are not very well understood. Early life stages of fish are particularly sensitive with the developing cardiac tissue being a main target of PAHs toxicity. The mechanisms of cardiotoxicity of the three widespread model polycyclic aromatic hydrocarbons (PAHs) retene, pyrene and phenanthrene were explored in rainbow trout (Oncorhynchus mykiss) early life sta  ...[more]

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