Effect of a 91 day long stay in weightlessness on the International Space Station on mouse skin physiology

ABSTRACT: Comparitive gene expression in skin between mice maintained in microgravity (0g) and normogravity (1g) environment. Six male C57Bl/J10 mice were housed for 91 days in the specially designed \Mouse Drawer System\ in weightlessness aboard the International Space Station. Three wild-type mice (WT) and three transgenic mice overexpressing the osteogneic factor PTN/OSF1 under the control of the human bone specific ostecalcin promoter (Tg) were used in the experiment. During the 3-month stay on the ISS, 3 mice unfortunately died leaving 2 Tg and 1 WT. \MDS tissue sharing program\ allowed several teams to study various tissues from these mice. Our aim was to investigate the effect of such a long period of microgravity on skin physiology by morphological, biochemical and genomewide analyses by co

INSTRUMENT(S): Mouse Drawer System, Scanner Genechip 3000 7G

ORGANISM(S): Mus musculus

SUBMITTER: Betty Nusgens 

PROVIDER: E-MTAB-2871 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress