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Genomic landscape of carcinogen induced mouse skin squamous cell carcinoma: RNA-sequencing

ABSTRACT: RNA-sequencing of induced murine squamous cell carcinoma.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Bram Boeckx

PROVIDER: E-MTAB-2889 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma.

Nassar Dany D Latil Mathilde M Boeckx Bram B Lambrechts Diether D Blanpain Cédric C

Nature medicine 20150713 8

Mouse models of cancers are routinely used to study cancer biology. However, it remains unclear whether carcinogenesis in mice is driven by the same spectrum of genomic alterations found in humans. Here we conducted a comprehensive genomic analysis of 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced skin cancer, the most commonly used skin cancer model, which appears as benign papillomas that progress into squamous cell carcinomas (SCCs). We also studied genetically induced SCCs that expressed G1 ...[more]

PMID: 26168291

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