Dataset Information
Toxicogenomic analysis in liver of mice exposed to polluted groundwater
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Fulvio D'Angelo
PROVIDER: E-MTAB-2905 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cross-species toxicogenomic analyses and phenotypic anchoring in response to groundwater low-level pollution.
BMC genomics 20141205
<h4>Background</h4>Comparison of toxicogenomic data facilitates the identification of deregulated gene patterns and maximizes health risk prediction in human.<h4>Results</h4>Here, we performed phenotypic anchoring on the effects of acute exposure to low-grade polluted groundwater using mouse and zebrafish. Also, we evaluated two windows of chronic exposure in mouse, starting in utero and at the end of lactation. Bioinformatic analysis of livers microarray data showed that the number of deregulat ...[more]
