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Genome wide pathway analysis using gene expression data of colonic mucosa in patients with Inflammatory Bowel Disease

ABSTRACT: To provide new steps on the role of altered gene expression in the pathogenesis of these diseases, we performed whole gene expression profiling by comparing the RNA from inflamed and non-inflamed colonic mucosa

INSTRUMENT(S): GeneChip Scanner 3000 7G, GeneChip hybridization Oven 640

ORGANISM(S): Homo sapiens

SUBMITTER: Massimo Carella

PROVIDER: E-MTAB-2967 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide Pathway Analysis Using Gene Expression Data of Colonic Mucosa in Patients with Inflammatory Bowel Disease.

Palmieri Orazio O Creanza Teresa M TM Bossa Fabrizio F Palumbo Orazio O Maglietta Rosalia R Ancona Nicola N Corritore Giuseppe G Latiano Tiziana T Martino Giuseppina G Biscaglia Giuseppe G Scimeca Daniela D De Petris Michele P MP Carella Massimo M Annese Vito V Andriulli Angelo A Latiano Anna A

Inflammatory bowel diseases 20150601 6

<h4>Background</h4>Ulcerative colitis (UC) and Crohn's disease (CD) share some pathogenetic features. To provide new steps on the role of altered gene expression, and the involvement of gene networks, in the pathogenesis of these diseases, we performed a genome-wide analysis in 15 patients with CD and 14 patients with UC by comparing the RNA from inflamed and noninflamed colonic mucosa.<h4>Methods</h4>Two hundred ninety-eight differentially expressed genes in CD and 520 genes in UC were identifi ...[more]

PMID: 25901971

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