Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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ChIPseq profile of RNA polymerase (pol II), the p65 subunit of NFkB, STAT1 and STAT2 in bone marrow derived macrophages after treatment with IFNb, heat-killed Listeria monocytogenes (hkL), or both.


ABSTRACT: Using ChIP-Seq analysis we define genes induced in macrophages through synergistic transcriptional activation by NFkB and the IFNb-activated transcription factor ISGF3.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Sebastian Wienerroither 

PROVIDER: E-MTAB-2972 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Response to interferons and antibacterial innate immunity in the absence of tyrosine-phosphorylated STAT1.

Majoros Andrea A   Platanitis Ekaterini E   Szappanos Daniel D   Cheon HyeonJoo H   Vogl Claus C   Shukla Priyank P   Stark George R GR   Sexl Veronika V   Schreiber Robert R   Schindler Christian C   Müller Mathias M   Decker Thomas T  

EMBO reports 20160212 3


Signal transducer and activator of transcription 1 (STAT1) plays a pivotal role in the innate immune system by directing the transcriptional response to interferons (IFNs). STAT1 is activated by Janus kinase (JAK)-mediated phosphorylation of Y701. To determine whether STAT1 contributes to cellular responses without this phosphorylation event, we generated mice with Y701 mutated to a phenylalanine (Stat1(Y701F)). We show that heterozygous mice do not exhibit a dominant-negative phenotype. Homozyg  ...[more]

Publication: 1/2

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