Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome analysis in macrophages treated with type I interferon, heat-killed Listeria monocytogenes, or both.


ABSTRACT: To define the group of genes which is synergistically induced by cooperative activity of the type I interferon - activated Jak/STAT pathway and other pathways, we treated bone marrow-derived macrophages (BMDM) with heat-killed Listeria (hkL; non-STAT pathways activated), type I interferon alone (only STAT pathway activated), or both stimuli together.

ORGANISM(S): Mus musculus

SUBMITTER: Sebastian Wienerroither 

PROVIDER: E-MTAB-3015 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex.

Wienerroither Sebastian S   Shukla Priyank P   Farlik Matthias M   Majoros Andrea A   Stych Bernadette B   Vogl Claus C   Cheon HyeonJoo H   Stark George R GR   Strobl Birgit B   Müller Mathias M   Decker Thomas T  

Cell reports 20150702 2


The transcriptional response to infection with the bacterium Listeria monocytogenes (Lm) requires cooperative signals of the type I interferon (IFN-I)-stimulated JAK-STAT and proinflammatory NF-κB pathways. Using ChIP-seq analysis, we define genes induced in Lm-infected macrophages through synergistic transcriptional activation by NF-κB and the IFN-I-activated transcription factor ISGF3. Using the Nos2 and IL6 genes as prime examples of this group, we show that NF-κB functions to recruit enzymes  ...[more]

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