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Global gene expression of bone marrow multipotent mesenchymal stromal cells isolated from type 1 diabetes patients and healthy donors

ABSTRACT: Microarray analysis of bone marrow multipotent mesenchymal stromal cells isolated from type 1 diabetes patients and healthy donors.

ORGANISM(S): Homo sapiens

SUBMITTER: Kalil Alves de Lima

PROVIDER: E-MTAB-2976 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Multipotent mesenchymal stromal cells from patients with newly diagnosed type 1 diabetes mellitus exhibit preserved in vitro and in vivo immunomodulatory properties.

Yaochite Juliana Navarro Ueda JN de Lima Kalil Willian Alves KW Caliari-Oliveira Carolina C Palma Patricia Vianna Bonini PV Couri Carlos Eduardo Barra CE Simões Belinda Pinto BP Covas Dimas Tadeu DT Voltarelli Júlio César JC Oliveira Maria Carolina MC Donadi Eduardo Antônio EA Malmegrim Kelen Cristina Ribeiro KC

Stem cell research & therapy 20160118

<h4>Background</h4>Type 1 diabetes mellitus (T1D) is characterized by autoimmune responses resulting in destruction of insulin-producing pancreatic beta cells. Multipotent mesenchymal stromal cells (MSCs) exhibit immunomodulatory potential, migratory capacity to injured areas and may contribute to tissue regeneration by the secretion of bioactive factors. Therefore, MSCs are considered as a promising approach to treat patients with different autoimmune diseases (AID), including T1D patients. Phe ...[more]

PMID: 26781648

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