Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

SAMHD1 restricts HIV-1 integration in human macrophages

ABSTRACT: Whole genome transcriptional profiling of human monocyte derived macrophages differentiated in the presence of human or foetal calf serm

ORGANISM(S): Homo sapiens

SUBMITTER: Mahdad Noursadeghi

PROVIDER: E-MTAB-2985 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

The effect of bacterial capsule on macrophage transcriptional responses to Streptococcus Pneumoniae.

Project description:Streptococcus Pneumoniae capsule is a major virulence factor. The capsule is known to inhibit complement fixation and phagocytes, but its impact on innate immune responses is not known. To address this question, we compared transcriptional responses by human monocyte derived macrophages in responses to wild type S. pneumoniae with isogenic mutant bacteria lacking their capsule. We conducted these experiments with and without macrophage pretreatment with cytochalasin D to evaluate the impact of phagocytosis, and we also made comparisons to mutant S.pneumoniae lacking bacterial lipoprotein which is known to be necessary for maximal innate immune responses.

2018-04-02 | E-MTAB-5894 | biostudies-arrayexpress

Paracrine activation of hCMEC/D3 cells by LPS-stimulated macrophages

Project description:Transcriptional profiling of hCMEC/D3 endothelial cells after six hour incubation with conditioned media from unstimulated or LPS-stimulated monocyte derived macrophages

2015-12-31 | E-MTAB-3692 | biostudies-arrayexpress

Transcriptional response by macrophages stimulated with selected cytokines or innate immune stimuli

Project description:Transcriptional response by macrophages stimulated with selected cytokines or innate immune stimuli

2016-02-09 | E-MTAB-3255 | biostudies-arrayexpress

Transcriptional response of LPS-stimulated monocyte-derived macrophages in the presence or absence of the anti-TNF agonist Etanercept

Project description:We measured TNFÎ± activity on the transcriptional level by identifying TNFÎ±-inducible genes in human blood monocyte-derived macrophages (MDM). On the basis that TNFÎ± does not act in isolation, we used bacterial lipopolysaccharide (LPS) as a prototypic model of a stimulus to invoke secretion of a wide range of immunologically active factors, including TNFÎ±. In order to identify gene expression attributable to LPS-induced TNFÎ±, we compared the transcriptome of MDM 24 hours after stimulation with 100 ng/ml ultra-pure LPS in the presence and absence of the soluble TNF receptor fusion protein Etanercept (10 Âµg/ml).

2017-08-04 | E-MTAB-5095 | biostudies-arrayexpress

Transcriptional response of monocyte-derived macrophages to stimulation with wildtype or pneumolysin-deficient Streptrococcus pneumoniae in the presence or absence of cytochalasin D

Project description:We used genome-wide transcriptional profiling by microarray to assess the contribution of pneumolysin on macrophage innate immune responses to the TIGR4 strain of Streptococcus pneumoniae (Spn). We focused on the early transcriptional responses at 4 hours after inoculation of human blood monocyte-derived macrophage cultures with Spn at a multiplicity of 10 bacteria to each cell. We compared transcriptomes in the presence and absence of wildtype or pneumolysin-deficient TIGR4 Spn, and also in the presence and absence of cytochalasin D to assess whether there is a differential effect of pneumolysin on innate immune responses with and without bacterial internalisation.

2021-03-31 | E-MTAB-8947 | biostudies-arrayexpress

Molecular profiling of the tuberculin skin test in patients with active tuberculosis with and without HIV-1 co-infection

Project description:Whole genome transcriptional profiling of punch biopsies from the site of 2U intradermal tuberculin or equivalent volume of saline injection at 48 hours after injection.

2016-02-09 | E-MTAB-3254 | biostudies-arrayexpress

Transcriptional profiling of the tuberculin skin test in patients cured of tuberculosis disease

Project description:Whole genome transcriptional profiling of punch biopsies from the site of 2U intradermal tuberculin or equivalent volume of saline injection at 48 hours after injection in patients that have been cured of active tuberculosis (TB) disease.

2019-05-01 | E-MTAB-6815 | biostudies-arrayexpress

Blood transcriptional profiling in HIV-negative healthy volunteers and HIV patients before and after three months of anti-retroviral therapy

Project description:Whole genome transcriptional profiling by microarray of blood taken from HIV-negative healthy volunteers (n=15), and HIV patients before (n=24) and after three months of anti-retroviral therapy (n=17). This submission includes two human whole genome Agilent Array Designs: A-AGIL-28 and A-GEOD-20844. Each of the individual raw array files are included as well as a single processed file representing the data matrix of all the merged and normalised data for the probes that are shared by the two array designs.

2021-02-26 | E-MTAB-8897 | biostudies-arrayexpress

Blood transcriptional profiling in patients with pulmonary tuberculosis before and at 2 weeks, 8 weeks and 2 years after treatment

Project description:Whole genome transcriptional profiling by microarray of 167 blood samples taken from 67 people with smear and culture-positive drug-sensitive pulmonary TB. Samples were taken pre-treatment (n=46), as well as two weeks (n=46), eight weeks (n=44) and two years (n=31) after treatment initiation. The two- and eight-week samples represent on-treatment timepoints, whilst the two-year timepoint reflects off-treatment convalescence. This submission includes two human whole genome Agilent Array Designs: A-MEXP-2102 and A-AGIL-28. Each of the individual raw array files are included as well as a single processed file representing the data matrix of all the merged and normalised data for the probes that are shared by the two array designs.

2024-12-04 | E-MTAB-13605 | biostudies-arrayexpress

Blood transcriptomic diagnosis of active tuberculosis and discrimination from other febrile illnesses

Project description:Whole blood transcriptional profiles of patients with (1) active pulmonary ['AdjuVIT active TB' and 'New active pulmonary'] and (2) extrapulmonary TB ['New active-extrapulmonary'] at time of diagnosis, (3) long-term recovery after treatment for active pulmonary TB ['AdjuVIT active TB'], (4) febrile illnesses presenting to hospital ['Fever mixed infection'] and (5) febrile pneumonia ['Fever pneumonia'] before antibiotic treatment, and (6) healthy vounteers. Each array sample represents a separate individual in each group. This submission includes two human whole genome Agilent Array Designs: A-MEXP-2104 and A-AGIL-28. Each of the individual raw array files are included as well as a single processed file representing the data matrix of all the merged and normalised data for the probes that are shared by the two array designs.

2016-10-28 | E-MTAB-4257 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data