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HGC-RACK1

ABSTRACT: MicroRNA microarray profiling analysis was performed on human gastric cancer HGC cells after RACK1 silenced or not

ORGANISM(S): Homo sapiens

SUBMITTER: Ling Chen

PROVIDER: E-MTAB-3484 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Loss of RACK1 Promotes Metastasis of Gastric Cancer by Inducing a miR-302c/IL8 Signaling Loop.

Chen Ling L Min Lingqiang L Wang Xuefei X Zhao Junjie J Chen Hua H Qin Jing J Chen Weidong W Shen Zhenbin Z Tang Zhaoqing Z Gan Qiangjun Q Ruan Yuanyuan Y Sun Yihong Y Qin Xinyu X Gu Jianxin J

Cancer research 20150721 18

Gastric cancer remains the third leading cause of cancer-related mortality worldwide, and invasion and metastasis of gastric cancer represent the major reason for its poor prognosis. In this study, we found that loss of the receptor for activated C-kinase 1 (RACK1) promoted the metastasis of gastric cancer by enhancing the autocrine expression of IL8 in vitro and in vivo. microRNA (miRNA; miR) array identified that RACK1 modulated the expression of a series of miRNAs, including the miR-302 clust ...[more]

PMID: 26199092

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