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Integrated and functional genomics analysis validates the relevance of the nuclear variant ErbB380kDa in prostate cancer progression

ABSTRACT: ChIP-on-chip experiments were performed on immortalized and tumour cell lines selected upon characterization of endogenous nuclear expression of an ErbB380kDa isoform. Among the 1840 target promoters identified, 26 were selected before ErbB380kDa-dependent gene expression was evaluated by real-time quantitative RT-PCR, providing evidence that ErbB380kDa exerted transcriptional control on those genes.

ORGANISM(S): Homo sapiens

SUBMITTER: Paule Séité

PROVIDER: E-MTAB-3499 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrated and functional genomics analysis validates the relevance of the nuclear variant ErbB380kDa in prostate cancer progression

Project description:ChIP-on-chip experiments were performed on immortalized and tumour cell lines selected upon characterization of endogenous nuclear expression of an ErbB380kDa isoform. Among the 1840 target promoters identified, 26 were selected before ErbB380kDa-dependent gene expression was evaluated by real-time quantitative RT-PCR, providing evidence that ErbB380kDa exerted transcriptional control on those genes.

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