Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional dysregulation mediated by ROS in normal human haematopoietic progenitor cells expressing mutant N-RASG12D

ABSTRACT: The current study investigated the effect of RAS-induced ROS production on gene expression in normal human haematopoietic progenitor cells (HPC) using gene expression profiling (GEP) and assessed whether ROS-induced gene expression changes contributed to the pro-proliferative phenotype. In order to determine the ROS-specific GEP, Affymetrix Human Exon 1.0ST arrays were used for the comparison of mutant RAS and control cells cultured in the presence or absence of the NOX inhibitor, DPI, which strongly suppressed the production of ROS.

ORGANISM(S): Homo sapiens

SUBMITTER: Goitseone Hopkins

PROVIDER: E-MTAB-3551 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional dysregulation mediated by ROS in normal human haematopoietic progenitor cells expressing mutant N-RASG12D

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