Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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RNA-seq of poly-A enriched total RNA of brain, liver, kidney, heart and skeletal muscle samples from mouse


ABSTRACT: This experiment contains the Mus musculus subset of data from the experiment E-GEOD-41338 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41338/). mRNA profiles of several organs (brain, liver, kidney, heart, skeletal muscle) in multiple vertebrate species (mouse, chicken, lizard, frog, pufferfish) were generated by deep sequencing using Illumina HiSeq to better understand how species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level.

ORGANISM(S): Mus musculus

SUBMITTER: Nuno Barbosa-Morais 

PROVIDER: E-MTAB-3725 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate species spanning ~350 million years of evolution, we observed significant differences in alternative splicing complexity between vertebrate lineages, with the highest complexity in primates. Within 6 million years, the splicing profiles of physiologically equivalent organs diverged such that they are more strongly related  ...[more]

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