Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Nuno Barbosa-Morais
PROVIDER: E-MTAB-3725 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Barbosa-Morais Nuno L NL Irimia Manuel M Pan Qun Q Xiong Hui Y HY Gueroussov Serge S Lee Leo J LJ Slobodeniuc Valentina V Kutter Claudia C Watt Stephen S Colak Recep R Kim TaeHyung T Misquitta-Ali Christine M CM Wilson Michael D MD Kim Philip M PM Odom Duncan T DT Frey Brendan J BJ Blencowe Benjamin J BJ
Science (New York, N.Y.) 20121201 6114
How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate species spanning ~350 million years of evolution, we observed significant differences in alternative splicing complexity between vertebrate lineages, with the highest complexity in primates. Within 6 million years, the splicing profiles of physiologically equivalent organs diverged such that they are more strongly related ...[more]