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Transcription profiling of human embryonic kidney cell line HEK293T to investigate the effects of overexpression of FoxO4 or mutated FoxO4 in presence or absence of p300

ABSTRACT: Effects of overexpression of FoxO4 or mutated FoxO4 in presence or absence of p300 overexpression

ORGANISM(S): Homo sapiens

SUBMITTER: Marian Groot Koerkamp

PROVIDER: E-MTAB-4 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity.

Dansen Tobias B TB Smits Lydia M M LM van Triest Miranda H MH de Keizer Peter L J PL van Leenen Dik D Koerkamp Marian Groot MG Szypowska Anna A Meppelink Amanda A Brenkman Arjan B AB Yodoi Junji J Holstege Frank C P FC Burgering Boudewijn M T BM

Nature chemical biology 20090802 9

Cellular damage invoked by reactive oxygen species plays a key role in the pathobiology of cancer and aging. Forkhead box class O (FoxO) transcription factors are involved in various cellular processes including cell cycle regulation, apoptosis and resistance to reactive oxygen species, and studies in animal models have shown that these transcription factors are of vital importance in tumor suppression, stem cell maintenance and lifespan extension. Here we report that the activity of FoxO in hum ...[more]

PMID: 19648934

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