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Genome-wide profiling of Alternative polyadenylation sites in mouse female germline stem cells

ABSTRACT: Alternative polyadenylation (APA) is an important post-transcriptional modification implicated in development. Female germline stem cell (FGSC) is unipotent and capable of giving rise to oocyte. However, whether alternative polyadenylation plays a role in self-renew and cell fate determination of FGSCs remain elusive. Here, we used 3T-Seq developed in our lab to profile genome-wide 3a termini of transcripts and delineate APA sites in mouse FGSCs and explored the biological significance of APA modulation in FGSC identity.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Jun Wu

PROVIDER: E-MTAB-4038 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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