Transcriptional effects of exogenous lipid on differentiated THP-1 cells
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ABSTRACT: Lipid laden macrophages (LLM) can often be found in the airway and may indicate aspiration secondary to gastro-oesophageal reflux (GOR). GOR is often associated chronic inflammatory airways diseases. We therefore sought to determine whether lipid droplets from undigested or partially digested food had an effect on macrophage gene expression leading to bronchial inflammation. To test this, we generated an in vitro model using differentiated THP-1 cells which were treated with a high fat liquid feed. Gene expression, using the Agilent G4851C (v3) array, in phorbol myristate acetate (PMA) differentiated THP-1 cells was compared to undifferentiated cells and lipid treated differentiated THP-1 cells.
ORGANISM(S): Homo sapiens
SUBMITTER: Dr Laura Sadofsky
PROVIDER: E-MTAB-4153 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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