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MicroRNA expression profiling in human ADPKD cell lines


ABSTRACT: Changes in microRNA expression levels were identified by microarray. Samples were human kidney epithelial cell lines derived from patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and unaffected controls. Autosomal Dominant Polycystic Kidney Disease (ADPKD), the most common inherited kidney disease, is due to mutations in PKD1 (85%) or PKD2 (15%) but has a highly variable phenotypic disease expression. We conducted parallel microarray profiling in normal and diseased human PKD1 cystic kidney cells to identify altered signatures of microRNA and mRNA target genes potentially implicated in disease expression. This dataset contains the results of the microRNA analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Streets 

PROVIDER: E-MTAB-4189 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Parallel microarray profiling identifies ErbB4 as a determinant of cyst growth in ADPKD and a prognostic biomarker for disease progression.

Streets Andrew J AJ   Magayr Tajdida A TA   Huang Linghong L   Vergoz Laura L   Rossetti Sandro S   Simms Roslyn J RJ   Harris Peter C PC   Peters Dorien J M DJ   Ong Albert C M AC  

American journal of physiology. Renal physiology 20170111 4


Autosomal dominant polycystic kidney disease (ADPKD) is the fourth most common cause of end-stage renal disease. The disease course can be highly variable and treatment options are limited. To identify new therapeutic targets and prognostic biomarkers of disease, we conducted parallel discovery microarray profiling in normal and diseased human <i>PKD1</i> cystic kidney cells. A total of 1,515 genes and 5 miRNA were differentially expressed by more than twofold in <i>PKD1</i> cells. Functional en  ...[more]

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