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A CTD phosphatase modulates eIF4AIII nucleocytoplasmic shuttling and nonsense-mediated mRNA decay

ABSTRACT: In this study, we identified the Arabidopsis RNA polymerase II C-terminal domain phosphatase-like protein, FIERY2 (FRY2, also known as CPL1), as a novel regulator of NMD.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Liming Xiong

PROVIDER: E-MTAB-4305 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A KH-domain RNA-binding protein interacts with FIERY2/CTD phosphatase-like 1 and splicing factors and is important for pre-mRNA splicing in Arabidopsis.

Chen Tao T Cui Peng P Chen Hao H Ali Shahjahan S Zhang Shoudong S Xiong Liming L

PLoS genetics 20131017 10

Eukaryotic genomes encode hundreds of RNA-binding proteins, yet the functions of most of these proteins are unknown. In a genetic study of stress signal transduction in Arabidopsis, we identified a K homology (KH)-domain RNA-binding protein, HOS5 (High Osmotic Stress Gene Expression 5), as required for stress gene regulation and stress tolerance. HOS5 was found to interact with FIERY2/RNA polymerase II (RNAP II) carboxyl terminal domain (CTD) phosphatase-like 1 (FRY2/CPL1) both in vitro and in v ...[more]

PMID: 24146632

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