Gene expression analysis in proximal and distal colons of Lcn2-/- IL10-/- double knock-out mice.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): GeneTitan Multi-Channel (MC) Instrument
ORGANISM(S): Mus musculus
SUBMITTER: Herbert Tilg
PROVIDER: E-MTAB-4583 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Lipocalin 2 Protects from Inflammation and Tumorigenesis Associated with Gut Microbiota Alterations.
Moschen Alexander R AR Gerner Romana R RR Wang Jun J Klepsch Victoria V Adolph Timon E TE Reider Simon J SJ Hackl Hubert H Pfister Alexandra A Schilling Johannes J Moser Patrizia L PL Kempster Sarah L SL Swidsinski Alexander A Orth Höller Dorothea D Weiss Günter G Baines John F JF Kaser Arthur A Tilg Herbert H
Cell host & microbe 20160401 4
High mucosal and fecal concentrations of the antimicrobial siderophore-binding peptide Lipocalin-2 (Lcn2) are observed in inflammatory bowel disease. However, Lcn2 function in chronic intestinal inflammation remains unclear. Here, we demonstrate that Lcn2 protects from early-onset colitis and spontaneous emergence of right-sided colonic tumors resulting from IL-10 deficiency. Exacerbated inflammation in Lcn2(-/-)/Il10(-/-) mice is driven by IL-6, which also controls tumorigenesis. Lcn2(-/-)/Il10 ...[more]
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