Unknown,Transcriptomics,Genomics,Proteomics

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The effect of Dicer knockdown on the microRNA transcriptional profile of 3.10 mTEC cell line.


ABSTRACT: Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short mature double-stranded RNA fragments called small interfering RNA and microRNA, respectively. MicroRNAs are potent post-transcriptional regulators in developmental switches, lineage commitment and gene expression regulation. To evaluate their post-transcriptional role in gene expression of Medullary thymic epithelial cells (mTECS) we knocked down Dicer transcript by means of siRNA transfection in a Mus musculus mTEC cell line (3.10 mTEC). The Agilent oligo microarrays were used to determine the large scale microRNA (miRNA) transcriptional profiles of control or Dicer-knockdown 3.10 mTECs.

INSTRUMENT(S): Agilent G2565AA and G2565BA Microarray Scanner

ORGANISM(S): Mus musculus

SUBMITTER: Geraldo Passos 

PROVIDER: E-MTAB-4627 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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