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Unknown,Transcriptomics,Genomics,Proteomics

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RNA expression in tongue squamous cell carcinoma, tumour free tongue tissue and control tongue

ABSTRACT: Tongue squamous cell carcinoma is a tumour type with rather low five year survival, around 60%. The poor survival rate has been ascribed to late detection, a high frequency of locoregional recurrence, the occurrence of secondary primary tumours and death due to comorbidity. One reason for development of recurrence is thought to be the existence of transformed cells in areas adjacent to the primary tumour, cancerization field effect. The aim of this study was to map the changes in the tumour free tongue tissue adjacent to tongue tumours compared with healthy control tongue tissue to better understand the cancerization field effect. Tissue biopsies were collected from tumour (T) and tumour free tissue adjacent to the tumour (TF) from patients with tongue squamous cell carcinoma. Control tissue was collected from latter border of the tongue of tumour free healthy volunteers (C). All samples were homogenized and RNA was extracted. The RNA was biotin labelled and run on Illumina HT-12 bead chip array.

ORGANISM(S): Homo sapiens

SUBMITTER: Linda Boldrup

PROVIDER: E-MTAB-4678 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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